IPA: /rɪˈɡrɛtfəli/
KK: /rɪˈɡrɛtfəli/
In a way that shows sadness or disappointment about something that has happened or been done.
Regretfully, I must decline your invitation to the party.
Regretfully → It is formed from "regret" (from Latin "regretare", meaning to weep or lament) and "-fully" (meaning in a manner full of). The word "regretfully" means in a manner full of regret or sorrow.
Think of feeling sorrowful or lamenting something when you act 'regretfully' — that's why it means to do something with regret.