IPA: /ˈnɛtəlˌsʌm/
KK: /ˈnɛtəlˌsʌm/
Causing annoyance or discomfort; irritating.
The nettlesome comments from the audience made the speaker uncomfortable.
Nettlesome → It is formed from "nettle" (from Old English *netele*, meaning a stinging plant) and "-some" (meaning characterized by or causing). The word "nettlesome" describes something that is characterized by causing irritation or annoyance, much like the stinging sensation of a nettle plant.
Think of the stinging plant 'nettle' that causes irritation, and remember that 'nettlesome' means something that causes annoyance or irritation.