IPA: /ˌɪrɪˈmɛdɪəbli/
KK: /ɪrɪˈmɛdɪəbli/
In a way that cannot be fixed or corrected; something that is beyond repair or improvement.
The damage to the ancient artifact was irremediably severe, making restoration impossible.
Irremediably → It is formed from "in-" (meaning not), "remediabilis" (from Latin "remedium", meaning remedy or cure), and "-ly" (meaning in a manner). The word means in a manner that cannot be remedied or cured.
Think of 'not' ('in-') being able to be 'cured' ('remedium') — that's why irremediably means something that cannot be fixed.