IPA: /ˌɪn.dɪˈfæt.ɪ.ɡə.bəl/
KK: /ɪnˈdɛfɪˌtɪgəbl/
Someone who is tireless and never seems to get tired, continuing to work or do things without stopping.
Her indefatigable spirit inspired everyone around her to keep going, no matter the challenges they faced.
Indefatigable is formed from "in-" (meaning not) and "defatigabilis" (from Latin "defatigare", meaning to tire out). The word describes someone who is not able to be tired out, hence, tireless or unflagging.
Think of someone who is 'not' ('in-') able to be 'tired out' ('defatigare') — that's why indefatigable means tireless.