IPA: /ɪɡˌzæ.sərˈbeɪ.ʃən/
KK: /ɪɡˌzæs.ərˈbeɪ.ʃən/
A worsening or intensification of a condition, often referring to a disease or problem becoming more severe.
The exacerbation of her asthma made it difficult for her to breathe.
Exacerbation → It is formed from "ex-" (meaning out of or from) and "acerbare" (meaning to make harsh or bitter). The word describes the act of making a situation worse or more severe, as if bringing out the harshness.
Think of 'bringing out' ('ex-') the 'harshness' ('acerbare') of a situation — that's why exacerbation means making something worse.