IPA: /dɪ'spɒndəns/
KK: /dɪ'spɑndəns/
A state of feeling sad, hopeless, or in low spirits, often due to a loss or disappointment.
After losing his job, he fell into a deep despondence that lasted for months.
Despondence is formed from "des-" (meaning down or away) and "spondere" (meaning to promise or pledge). The word describes a state of being downcast or lacking hope, as if one has broken a promise to oneself about happiness or fulfillment.
Think of feeling 'down' ('des-') as if you've 'broken a promise' ('spondere') to be happy — that's why despondence means a state of hopelessness.