IPA: /ˌæn.tiˈhɪs.tə.miːn/
KK: /ˌæntiˈhɪstəˌmin/
A type of medicine that helps relieve allergy symptoms by blocking the effects of a substance called histamine in the body.
She took an antihistamine to help with her hay fever symptoms.
Antihistamine is formed from "anti-" (meaning against) and "histamine" (from Greek "histaminē", meaning tissue). The word refers to a substance that works against histamine, which is involved in allergic reactions.
Think of 'anti-' meaning against, and 'histamine' being a substance related to tissue reactions — that's why antihistamine is something that works against tissue reactions like allergies.